Sentence examples for maintain normal protein from inspiring English sources

At least two models can explain this paradox: First, a transcription-independent mechanism exists to maintain normal protein or activity levels to cope with reduced expression in the delg mutant.

One interpretation is that mRNA levels in the Ts65Dn are depressed as a feedback mechanism to maintain normal protein levels.

It has long been speculated and recently shown in a few studies that extra copies of the subunits in some protein complexes would be degraded in order to maintain normal protein complex stoichiometry in the cell (Goldberg and Dice 1974; Geiger et al. 2010; Stingele et al. 2012).

Lei et al, found that in animals that were subjected to conditional deletion of Pten in prostate epithelium, Nkx3.1 levels were reduced [77], indicating that wildtype Pten levels are required to maintain normal Nkx3.1 protein levels.

These data indicate that the MP1 and/or p14 are required to maintain normal paxillin protein levels.

Biotin is a vitamin that mammalian cells cannot produce, and they depend on a constant supply of biotin from the intestinal microbiota to maintain normal levels of protein biotinylation.

Clones of H99 mutant cells do not show the same effect (Figure S2), indicating that ept is required to maintain normal levels of Rbf1 protein in eye-antennal disc cells.

Skeletal muscle phenotype and mitochondrial content depend on the coordinated expression of nuclear and mitochondrial encoded genes, as well as the synthesis and degradation of proteins to maintain normal muscle function.

ER retrieval meditated by Erd2p has been suggested as an non-essential process as Ire1p was reported to share functional redundancy to maintain normal levels of ER residential proteins in yeast [ 33].

The knock-in allele, referred to as VCL-ΔIn20/21 VCL-ΔIn20/21d wash the intent to maintain normal expression of vinculin mRNA andesignedn, and subsequently, to allowithe recombinase-conthelled intentuctoon of maintains inormals 20 to 22 at thexpressionus of vinculin (suppl. informRNAon, Fig. S1).

The acknowledged importance of autophagy in maintaining normal bulk protein recycling in these diseases has led to interest in whether pharmacological stimulation of autophagy could provide therapeutic benefit by delaying or preventing protein aggregate accumulations in disorders such as Huntington disease.