Such changes could be associated with an attempt within the tissues to maintain normal activity in the presence of depleted SMN function.
After 24 hours, in order to complete metamorphosis and maintain normal activity, trehalose was excessively hydrolyzed into glucose, resulting in enough glucose for the larva-pupa stage.
The healthy mitochondria produce much more energy than that required to maintain normal activity, a fact that changes with aging.
While many patients are able to maintain normal activity schedules, others experience debilitating fatigue that leads to dose limitation or treatment discontinuation [ 13].
Acupuncture was successfully employed, with the authors claiming that by allowing her to maintain normal activity her quality of life had been improved.
The patients were asked to grade their usual headache intensity as mild (maintaining normal activities without problems), moderate (maintaining normal activities with difficulty), severe (must give up normal activities and lie down) or extremely severe (impossible to stay still).
Indeed, normal stem cells will also be impacted by inhibiting drug transporters, especially ABCB1/MDR1 and ABCG2, both of which are important in maintaining normal activities in the blood-brain barrier [54].
This mechanism may be critical to maintaining normal activity-dependence of mGlu5 activation and achieving optimal in vivo effects.
Since engaging in play is so important for normal social and physical development [ 102], the consensus-based criteria for good symptom control are more stringent than for older age-groups, with an emphasis on assessing and maintaining normal activity levels.
