More importantly, mutations in several DUBs in humans have been identified in diseases, such as cancer, neurodegenerative diseases, and inflammatory diseases (Nijman et al. 2005; Singhal et al. 2008; Hussain et al. 2009; Huang et al. 2011), suggesting that the activity of DUBs must be tightly regulated in order to maintain the necessary levels of ubiquitination.
But, it is also possible that STAT1-activated gene expression requires regulation from the chromatin environment that is distinct from that needed during NR-activated gene expression, and that MEN1 contributes by establishing and maintaining the necessary levels of H3K4me2 at STAT1-dependent promoters.
"South Korea cannot maintain the necessary level of military preparedness under these circumstances.
However, those who decide such matters must have realised that, with his leftish tendencies and unpredictable sense of humour, Arnold could not be relied on to maintain the necessary level of imperial bombast without doing something silly.
Bourne and Wright have every reason to steer clear of Russia, and of course in publicising their reasons they have helped to maintain a necessary level of concern over Russia's treatment of its LGBT community.
It is the first time a supermarket has been prosecuted under the Packaging (Essential Requirements) Regulations, which demands that wrapping is "limited to the minimum adequate amount to maintain the necessary level of safety, hygiene and acceptance".
It is specially thought to achieve a better efficiency and to maintain the necessary level of the oxygen in the cathode to prevent short circuit and membrane damage.
Maintaining the necessary level of the resting membrane potential (RMP) in skeletal muscles is obligatory for successful functioning of the neuromuscular system [ 3, 4].
The recent campaign has ensured that the Ministry of Health's target for measles immunization in 2003 has been fully met, although to maintain the necessary coverage levels to interrupt the transmission of the measles virus continued efforts will be made to immunize children through routine vaccination activities.
