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Multiple studies revealed that H2S donors help maintain mitochondrial integrity, reduce the release of mitochondrial death signals, and attenuate mitochondrially-regulated cell death responses of various types 79, 81, 82.
Our studies demonstrate that Grx1, a cytosolic oxido-reductase, helps maintain mitochondrial integrity and prevents MMP loss caused by oxidative insult.
TEM analysis of young and aged human neurons lacking PINK1 also revealed an increase in the proportion of abnormal swollen mitochondria within cells (Figure 5F,G) further supporting the hypothesis that PINK1 functions to maintain mitochondrial integrity in neurons.
All steps were performed at 4°C to maintain mitochondrial integrity.
Furthermore, mitochondrial dynamics such as the fission and fusion processes are important to maintain mitochondrial integrity.
All procedures were performed at 4 °C to maintain mitochondrial integrity.
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While no consensus has been reached, it appears likely that both Omi and Parkin act via parallel pathways, with respect to Pink-1, in maintaining mitochondrial integrity.
All of this has led to a multi-factorial mechanism for maintaining mitochondrial integrity, where the role of OMI was downstream of Pink-1 (which in turn was upstream of Parkin), but was independent of Parkin [29], [31], [32].
Anti-apoptotic Bcl-2 proteins sequester pro-apoptotic Bcl-2 proteins, thus maintaining mitochondrial integrity.
Reviewer 3: MUL1 compensates for loss of PINK1/parkin in maintaining mitochondrial integrity.
Hence, by maintaining mitochondrial integrity, basal p53 activity may also limit ROS production.
More suggestions(16)
maintains mitochondrial integrity
maintain academic integrity
maintain mitochondrial viability
maintain mitochondrial cristae
maintain mitochondrial function
maintain chromosomal integrity
maintain structural integrity
maintain mitochondrial gene
maintain mitochondrial homeostasis
maintain mitochondrial morphology
maintain mitochondrial hyperpolarization
maintain mitochondrial fitness
maintain mitochondrial polarization
maintain mitochondrial respiration
maintain synaptic integrity
maintain mitochondrial membrane
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