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We postulate that long term PRC inhibition by ShRNA could induce compensatory mechanisms to maintain mitochondrial functions used for other cellular metabolisms.
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We also demonstrate that Blm10 acts to maintain mitochondrial function.
These processes serve to maintain mitochondrial function and ensure optimal energy supply for the cell.
In this context, autophagy is essential for synthesis of minimal essential proteins to maintain mitochondrial function during nitrogen starvation.
Indeed, there was partial activation of the mitochondrial biogenesis pathway involving NRF2α/GABP and its target genes TFAM, TFB1M and TFB2M yet clearly this failed to maintain mitochondrial function.
Regulation of autophagy and especially the autophagic degradation of mitochondria is an essential tool to maintain mitochondrial function and cellular homeostasis.
Mitochondrial dysfunction has been linked to neuronal cell loss in PD and it seems likely that the genes associated with recessive parkinsonism help maintain mitochondrial function under stressful conditions.
In this scenario, the main purpose of mitochondrial SOD is not to limit global oxidative damage but to maintain mitochondrial function by preventing the superoxide "rheostat" [51] from engaging.
Similarly, Pnc1p induction in mistranslating cells could prevent cell death and could maintain mitochondrial function by clearing nicotinamide inhibition and promoting NAD recycling and, thus, modulate the activity of other NAD+-dependent histone deacetylases.
Several mitochondrial stress response pathways that maintain mitochondrial function have been described.
Therefore, like mitochondrial fusion, fission seems to be required to maintain mitochondrial function.
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