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In order to minimize exposure to the host immune system and at the same time maintain its adherence properties, expression of the protein is epigenetically regulated such that only one copy of the encoding var gene repertoire is active per parasite at a given time, while the remaining approximately 60 variants are transcriptionally silent.
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Renaissance, which would not be interviewed for this article, has issued a statement saying: "Our high volume of passengers keeps our prices low and therefore Renaissance Cruises must maintain strict adherence to its cancellation policies.
Moreover, the provision of basic pharmaceutical care and adverse event management was sufficient to maintain adherence in initially adherent patients for at least six cycles.
Person with HIV often find it difficult to maintain the adherence necessary for viral suppression due to many factors, including depressive symptoms; [ 10] even infrequent non-adherence greatly diminishes efficacy [ 2, 11, 12].
Especially in the older population it is difficult to maintain high adherence to training programs [ 57].
Duration may be a function of power relationships: a dominant coalition member or set of members may be able to either dissolve the coalition or maintain ongoing adherence.
Patients initiating ART and surviving the first three months of therapy typically have improved survival outcomes in the long term if they can maintain optimal adherence [14].
Because of the potential difficulty for certain individuals to maintain strict adherence to such cycles, we reasoned that more "user-friendly" short cycle ARV interruption approaches could have greater implementation feasibility and clinical relevance.
The findings highlight the need for more effective interventions to maintain high adherence over time.
Successful antiretroviral therapy (ART) requires HIV-positive patients to maintain high adherence to medication regimes [ 1– 4].
This can result in both donors and recipients lacking enough drugs to maintain adequate adherence[ 29].
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