In this study, some of the amino acids of SMAP-29 were changed in an attempt to reduce haemolytic activity whilst maintaining high antibacterial efficacy.
This illustrates the need for a new vaccine concept that maintains high protective efficacy regardless of the antigenic variations that arise frequently due to antigenic drift.
For economic benefits to be realized, tigecycline will have to maintain high rates of clinical success against organisms resistant to other drugs, with sustained efficacy as empiric therapy in cases where other agents may fail.
This poor efficacy might be because of the fact that conventional antihypertensive therapies are aimed at downstream peripheral mechanisms which maintain high systemic arterial blood pressure, while primary factors responsible for the development of the condition remain untreated.
The efficacy of this approach is also dependent on the ability of the liver to efficiently secrete the modified sulphamidase in the blood stream, in order to maintain high and stable levels of circulating enzyme available to reach the brain.
A correct taking of DDAs is crucial to maintain a high efficacy of treatment [ 12, 13], minimizing the risk of viral resistance to DAAs.
Therefore, screening for new agents capable of treating peptic ulcers needs to continue in order to find compounds with reduced side effects while maintaining high-therapeutic efficacy.
Effective monitoring of resistance is vital for maintaining a high efficacy of the currently available anthelmintics and for preventing further selection for resistance, especially in areas where AR is present in only a small proportion of the worm population.
To improve the efficacy of the evolutionary process while maintaining high accuracy, we apply a quantitative structure property relationship (QSPR) model that relates molecular structure descriptors calculated at the semi-empirical level to experimentally determined pKa values.
YIP interns maintained high levels of STEM interest, career awareness, and self-efficacy.
