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Patients who did not maintain graft function for at least 1 year post-transplant were excluded.
However, some of the immunosuppressive agents commonly used to maintain graft function in islet recipients are known to raise blood pressure and cause lipid abnormalities two major risk factors for cardiovascular events.
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Furthermore, we cannot completely exclude the possibility that 25-OHD has another independent role in maintaining graft function not mediated by 1,25- OH 2D 1,25- OH 2D
Pretransplant 25-OHD deficiency was significantly associated with a lower post-transplant eGFR, suggesting that 25-OHD may play an important role in maintaining graft function after KT. 25-hydroxy vitamin D (25-OHD) is not only the stored form of vitamin D in the human body but also the predominant circulating form of vitamin D in the blood.
One hundred and twenty-six adult patients who (i) received a renal allograft under TAC-based immunosuppression at Akita University Hospital between February 2002 and August 2011, (ii) had no serious complications, and (iii) maintained graft function for at least one year after transplantation were eligible for this study.
Once the failing vein graft is identified and characterized, the clinician must choose the appropriate intervention to maintain graft patency.
However, not all ABMR phenotypes have poor outcomes, and many patients maintain stable graft function for years after treatment of the initial injury.
During the preceding three months, she had maintained normal graft function and did not receive any anti-rejection therapy.
She was maintaining normal graft function with prednisolone 10 mg once a day with a plan to introduce azathioprine.
However, the rate of insulin independence may progressively decline after transplantation, reaching ∼10% at 5 years despite maintaining islet graft function (5).
With these measures, she recovered completely and maintained good graft function despite being on only prednisolone 10 mg once a day.
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