While such recombination events in plant mitochondria increase the complexity of their genome structures, recombination has also been proposed to maintain genomic stability and may also provide a mechanism to increase genetic variation in the absence of sexual reproduction.
While such events in plant mitochondria increase organelle genome complexity, recombination has also been found to maintain genomic stability and may provide a mechanism to increase genetic variation in the absence of sexual reproduction [ 58].
Thus, hypermethylation of repeat elements in the horse genome might play an essential role, as a defense mechanism to maintain genomic stability in the presence of active repeat elements.
The study of the mycoplasma repair system, as bacteria with a reduced genome, gives an indication of the minimum number of genes required to maintain genomic stability.
These reviews are an essential step towards a definition of RDAs designed to maintain genomic stability.
MMR maintain genomic stability by correcting mismatches generated during DNA replication, their malfunction promoting cancer due to microsatellite instability [24].
There is mounting evidence suggesting that CSCs employ alternative DNA repair pathways to maintain genomic stability and prevent damage from radiotherapy.
It would be interesting to further explore whether telomeres are effectively elongated to maintain genomic stability of SCNT ES cells achieved using oocyte factors.
Chromosome replication, gene expression and chromatin assembly all occur on the same template, necessitating a tight spatial and temporal coordination to maintain genomic stability.
More interestingly, an ALT-like mechanism is also activated during this process to rapidly elongate the telomeres, wherein Zscan4 is involved to maintain genomic stability, (Varela et al., 2011; Zalzman et al., 2010).
These results suggest that DNA repair pathways other than HR may determine sensitivity to PARP inhibitors and highlight the likelihood that ostensibly distinct DNA repair pathways cooperate to maintain genomic stability and cellular viability.
