This research reveals that INO80 and SWR1 ATP-dependent chromatin remodelling is an integral component of pathways that maintain genomic integrity.
Overall, in the pathogen it appears that Mms22p plays a critical role in preserving genome integrity during DNA replication; perhaps Mms22 functions to maintain genomic integrity by HR through coordination of DNA synthesis by interacting with Rtt101p in the rescue of paused replication forks after they confront a block.
Ciccia, A. et al. Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress.
Processing was suppressed for DNA ends that could be ligated directly, biasing the reaction to preserve DNA sequence and maintain genomic integrity.
Ciccia A, Nimonkar AV, Hu Y, Hajdu I, Achar YJagadheesh, Izhar L, et al. Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress.
Collectively, this work emphasizes the importance of collecting quantitative dynamic information in single cells in order to gain a comprehensive understanding of how different DNA damage response pathways function in a coordinated manner to maintain genomic integrity.
DNA repair pathways maintain genomic integrity and stability, and dysfunction of DNA repair leads to cancer.
The ability of our cells to maintain genomic integrity is fundamental for protection from cancer development.
DNA repair and DNA damage checkpoints work in concert to help maintain genomic integrity.
As expected, most of these functions are associated with basic cellular processes that maintain genomic integrity (transcription factors, polymerases, etc).
The BRCA1 protein functions in multiple pathways that maintain genomic integrity through its impact on the repair of a variety of genomic lesions including DNA double-strand breaks (DSBs).
