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All of the above processes are crucial for a cell's ability to maintain genomic fidelity.
The slight elevation in p53 may help maintain genomic fidelity during early life, resulting in healthier, longer-lived adults, at the cost of developmental speed and elevated energy requirements.
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DNMT3L is not expressed in differentiated somatic cells, yet unlike Dnmt3L-deficient ES cells, they are able to maintain genomic methylation patterns with high fidelity.
ESCs may use several mechanisms to maintain genomic stability including the up-regulation of DNA repair, the utilization of high-fidelity forms of repair, and the efficient elimination of damaged cells by apoptosis [ 2- 5].
These reviews are an essential step towards a definition of RDAs designed to maintain genomic stability.
In response to genomic shock, the siRNAs maintain genomic stability in allopolyploids [ 13].
Therefore, both G1/S and G2/M checkpoints are important for maintaining genomic stability, an essential requirement for the fidelity of transmission of intact genomes to cellular progeny (Hartwell, 1992; Paulovich et al, 1997).
Homologous recombination is required for maintaining genomic integrity by functioning in high-fidelity repair of DNA double-strand breaks and other complex lesions, replication fork support, and meiotic chromosome segregation.
Homologous recombination (HR) is a conserved mechanism of high-fidelity DNA repair necessary for maintaining genomic stability.
DNMT1 maintains genomic DNA methylation at 5′-CpG-3′ residues in somatic cells.
Nuclear PTEN might play a role in maintaining genomic stability [7].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com