It has been reported that insertions of new horizontally acquired genetic material could trigger compensating genomic rearrangements in order to maintain genome stability [ 26].
Bermejo, R., Lai, M. S. & Foiani, M. Preventing replication stress to maintain genome stability: resolving conflicts between replication and transcription.
Bétous, R. et al. SMARCAL1 catalyzes fork regression and Holliday junction migration to maintain genome stability during DNA replication.
Bermejo, R., Lai, M. & Foiani, M. Preventing replication stress to maintain genome stability: resolving conflicts between replication and transcription.
Yan, Z. et al. A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability.
Wang, Y. et al. FANCM and FAAP24 maintain genome stability via cooperative as well as unique functions.
All three of these functions maintain genome stability during cell division.
Attrition of telomeres, chromatin structures that help maintain genome stability, leads to cell death or senescence.
DNA damage/repair constitutes several key pathways working in concert to eliminate DNA lesions and maintain genome stability and integrity.
Among other subjects, they study the mechanisms that maintain genome stability, such as DNA repair, the cellular responses to DNA damage and the mechanisms that control telomere length.
Michael, who joined the MCB faculty in 2000, studies mechanisms and pathways that maintain genome stability, using biochemistry in Xenopus egg extracts together with genetic analysis in C. elegans.
