The foregoing discussion suggests that failures in a number of different processes that maintain genome integrity could contribute to the wide variety of genomic alterations in solid tumors.
The mechanisms leading to genomic instability are multiple as multiple different systems exist which maintain genome integrity and which target different forms of DNA damage.
In eukaryotic organisms, the replication of the DNA sequence and its organization into chromatin are critical to maintain genome integrity.
DNA ligases join single-strand breaks in double-stranded DNA, and are essential to maintain genome integrity in DNA metabolism.
We speculate that the DSB repair machinery can utilize the context-dependent chromatin environment to access and repair the DSB and maintain genome integrity.
He has found that the replisome can overcome bulky obstacles on a DNA strand, such as DNA-protein cross-links (DPCs), during replication to maintain genome integrity.
Kirkman L, Lawrence B and Deitsch K. Malaria parasites utilize both homologous recombination and alternative end joining pathways to maintain genome integrity.
Understanding how cells react to DSB and maintain genome integrity is of major importance, since increasing evidences indicate the links of DSB with genome instability and cancer predispositions.
Eukaryotic DNA replication is a complex process requiring the proper functioning of a multitude of proteins to create error-free daughter DNA strands and maintain genome integrity.
During cell division, chromosomes must faithfully segregate to maintain genome integrity, and this dynamic mechanical process is driven by the macromolecular machinery of the mitotic spindle.
