Sentence examples for maintain gene silencing from inspiring English sources

We also found H2AFY, which is a macroH2A1 enriched on the inactive X chromosome in female mammalian cells, where it functions to maintain gene silencing [69].

These modifications in H3.3 and H4 from the fat of female subjects are in line with identification of H2AFY and the protein "similar to H2AFY2", the variant histones that most probably function to maintain gene silencing and inactive X chromosome in female mammalian cells [69].

Polycomb group (PcG) proteins are epigenetic repressors that maintain gene silencing of important regulators of development, such as Hox genes.

In particular PcG proteins exert epigenetic "memory" function by modifying chromosome structures at various levels to maintain gene silencing in particular through cell division.

The original report that ubiquitinated H2A protein helps to maintain gene silencing has been controversial, as this mark was also found in transcribed chromatin regions of D. melanogaster.

Vertebrate ATF-2 also interacts with the histone variant macroH2A, which is enriched in the inactive X chromosome in female mammalian cells and functions to maintain gene silencing (Agelopoulos & Thanos 2006).

It has also been proposed that DNA methylation primarily acts to stabilize patterns of endogenous gene activity by maintaining gene silencing that was build by other means [7].

This is consistent with a recent study showing that EZH2 functions to maintain the low expression of target genes that lack DNA methylation but is not required for maintaining gene silencing predominantly caused by DNA methylation [34].

HP1 recognises this 'OFF' mark and maintains gene silencing.

For example, methylation appears to play a role in maintaining gene silencing in genomic imprinting [ 26].

The relationship between histone modifications and DNA methylation in maintaining gene silencing has been studied at the chromosomal level [ 28].