Sentence examples for maintain gene repression from inspiring English sources
PolycombGroup (PcG) proteins maintain gene repression through histone modifications and have been implicated in stem cell regulation and cancer.
Our findings are supported by recent reports that suggest that XIST is expressed in adult well-differentiated cells in order to maintain gene repression [ 35- 39].
LincRNA-p21 is associated with heterogenous nuclear ribonucleoprotein K and localises this protein to promoters of genes, downregulated in the canonical p53 pathway and p53-mediated apoptosis, to maintain gene repression.
It is widely accepted that methylation at CpG residues functions as an important mechanism for maintaining gene repression [ 1].
Collectively, our global gene expression analysis supports broad roles for Brg1 in gene activation and maintaining gene repression of key developmental regulators during mesoderm differentiation of ESCs.
Polycomb group (PcG) proteins maintain gene expression patterns during development in animals and plants by establishing a cellular memory system for transcriptional repression [1].
By means of chromatin remodeling, PcG proteins maintain stable gene repression to ensure proper embryonic development.
Specifically, various studies indicate that a number of key developmental and pluripotency genes are marked by bivalent marks of chromatin activation (H3K4me3) and repression (H3K27me3) that maintain genes in a "transcription-ready" state that allows rapid transcription activation upon differentiation of ESC [4], [5].
Recent studies in mouse embryonic stem cells have suggested the coordinated regulation of H3K4 demethylation and PRC2-mediated repressive histone modifications in maintaining transcriptional gene repression [60].
Recent studies suggest that LHP1 specifically recognizes and binds to H3K27me3 deposited by PRC2-like complexes to maintain stable transcriptional gene repression [37], [38].
Polycomb-group genes (PcG) encode proteins that maintain homeotic (Hox) gene repression throughout development.
