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They are found in close proximity to coding sequences (∼UTR regions) or within canonical intron sequences, but never in coding sequences where they are counter-selected for to maintain gene functionality.
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Apparent parallelism may point to a common mechanism of 5 S integration, and/or similar selection pressures in different organisms maintaining gene functionality.
Nevertheless these current data show that hSCs seeded on the scaffold maintain their functionality regarding trophic factor secretion.
As in other studied dipteran dsx homologs, the gene maintains functionality via evolutionarily conserved protein domains and sex-specific alternative splicing.
To date, the fragmented metabolic pathways of endosymbionts have been shown to maintain functionality through complementation by host genes, complementation by genes of another endosymbiont and complementation by genes in host genomes that have been horizontally acquired from a microbial source that is not the endosymbiont.
Strikingly, expression of most transcription factors necessary to maintain islet functionality, with the notable exception of the downregulation of Nfe2l2 (Nrf2), a gene protecting beta cells from oxidative stress [ 33], was upregulated, suggesting an effort towards functional compensation (Fig. 2d and ESM Table 1).
"You cannot sterilize tissue and maintain its functionality," Dr. Fronk said.
Greider and Blackburn found that telomerase adds DNA to telomeres and thereby helps maintain the functionality of chromosomes.
These proteases are responsible to degrade key proteins that maintain the functionality of the BBB.
He usually trains with opponents who maintain full functionality.
In contrast, the low Ka/ Ks ratios for the 5-exon/4-intron GTLP genes (e.g., 0 to <0.01) indicate strong purifying selection pressure to conserve the encoded amino acid sequence in order to maintain protein functionality.
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