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Importantly, in cBAF-perturbed cancers, ncBAF complexes maintain gene expression at retained CTCF-promoter sites and function in a manner distinct from fusion oncoprotein-bound complexes.
Polycomb group (PcG) proteins are essential to maintain gene expression patterns during development.
Polycomb group (PcG) proteins maintain gene expression patterns during development in animals and plants by establishing a cellular memory system for transcriptional repression [1].
As described below, we expect that weak selection to maintain gene expression stability may result in positive selection on certain compensatory regulatory changes in spite of the fact that most novel alleles are likely to be deleterious.
Fsh is a Trithorax group protein, whose main action is to maintain gene expression.
DNA methylation is a normal procedure to maintain gene expression with normal patterns in mammalian cells.
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In both instances, we observed more downregulated than upregulated genes, suggesting that BRD9 generally maintains gene expression.
Supplementary Figure 6 BRD9 maintains gene expression at retained, CTCF-marked promoter sites in BAF-perturbed settings of synovial sarcoma and malignant rhabdoid tumor.
Finally, in vivo experiments showed that the biodegradable HES markedly reduced the non-specific lung transcription of the polyplexes, but maintained gene expression in the tumor, contrary to the non-degradable HES and PEG controls, which reduced both tumor and lung expression.
In general, therefore, the data showed that p56Lck, and thus the TCR signal, is more important for maintaining gene expression than for repressing it.
In order to favour biologically maintained gene expression changes, we filtered the data to identify genes that were significantly regulated (p≤0.05) in each of the two cohorts, rather than relying on overall statistical significance in the study.
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preserving gene expression
sustaining gene expression
maintenance gene expression
sustained gene expression
maintains gene expression
maintained gene expression
maintain gene silencing
maintain gene structure
maintain gene functionality
maintain gene activity
maintain telomerase expression
maintain protein expression
maintain surface expression
maintain gene function
maintain gene order
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