Sentence examples for maintain functional mtDNA from inspiring English sources

In particular, cells lacking Mdj1, an Hsp40 co-chaperone of Hsp70 in the mitochondrial matrix, do not maintain functional mtDNA.

The plasmid shuffling strategy was used to maintain functional mtDNA owing to the presence of the wild-type MIP1 gene on an URA3 vector, which could subsequently be eliminated by 5-FOA counterselection (Sikorski and Boeke 1991).

While mutants lacking other mitochondrial nucleoid proteins such as Abf2 maintain functional mtDNA, if "forced" to grow on non-fermentable carbon sources [26], respiratory competent mdj1-∆ cells have not been obtained even under such circumstances.

Thus, we conclude, that Mdj1's function in maintaining functional mtDNA requires its co-chaperone activity as part of the Hsp70 chaperone system.

Maintaining muscle function is vital to maintain functional independence.

mtDNA is extremely compact (93% coding sequence) and the majority of proteins required to build and maintain functional mitochondria is therefore encoded by nuclear DNA, synthesized in the cytosol and imported into mitochondria, where they are targeted to one of the four mitochondrial compartments.

Gu, C. et al. Pancreatic beta cells require NeuroD to achieve and maintain functional maturity.

For instance, TRiC is required to maintain functional TCAB1, a co-factor of telomerase.

Being an ambassador is about working to maintain functional relationships.

It helps them to maintain functional ability to some extent.

Therefore, PA has a significant role in maintaining functional fitness.