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The heterologous ACC2 harbors all necessary posttranslational biotinylation and phosphorylation, vital to maintain functional integrity.
These results demonstrate that anti-apoptotic Bcl-2 proteins maintain functional integrity of mitochondria in HaCaT-derived SCC.
These findings convey that divergent ZsMATα genes are under a selective driving force aimed to maintain functional integrity of the encoded transcription factors.
Exposure of living matter to radiation induces a broad range of modifications that cells remove to maintain functional integrity and prevent tumor formation.
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Chaperone protein Hsp90 maintains functional integrity and maturation of a large number of cellular proteins including transcription factors, kinases, etc.
Since CD4+ T cells constitute the major IL-2 producing population that is important for maintaining functional integrity of other immune effectors including CD8+ T cells, a loss of IL-2 producing capacity of CD4+ T cells could produce a domino effect eventually for the overall immune deficiency.
We showed that whereas maintained functional integrity of the RVLM interfaces the vital window between resumption of spontaneous circulation and cardiac arrest, necrotic cell death as a result of bioenergetic failure triggered by anoxia in the RVLM underlies brain stem death and negates cardiac resuscitation.
Based on this experimental index, we were able to reveal the novel finding that a crucial determinant for successful revival of cardiac arrest is that spontaneous circulation must resume before brain stem death commences, and that maintained functional integrity of the RVLM, leading to sustained sympathetic vasomotor tone, holds the key to this vital time-window.
We conclude that whereas necrotic cell death because of bioenergetic failure triggered by anoxia in RVLM, which precipitates brain stem death, negates resuscitation of an arrested heart, maintained functional integrity of this neural substrate holds the key to resumption of spontaneous circulation after cardiac arrest in rats.
Here, we evaluated the hypothesis that maintained functional integrity of the rostral ventrolateral medulla (RVLM), a neural substrate that is intimately related to brain stem death and central circulatory regulation, holds the key to the vital time-window between cardiac arrest and resumption of spontaneous circulation.
The amino acid glutamine plays an important role in maintaining functional integrity of the gut.
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