Adult SCs maintain expression of OCT4, and because CSCs express this gene, this suggests tumor cells are derived from normal SCs (Tai et al. 2005).
Mase et al. found that many miRNAs in the let-7 family are expressed in human ovarian granulosa KGN cells, which maintain expression of FSH receptors.
Undifferentiated 5T4-GFP ES cells lack EGFP and maintain expression of the pluripotent markers OCT-4 and NANOG.
TCR-transduced PBMC also secrete IFN-γ upon coculture with LMP2 targets and maintain expression of the transduced TCR during subsequent mitogenic expansion.
These results suggest that in normal sex determination, zebrafish oocytes passing through meiosis signal the gonadal soma to maintain expression of aromatase, an enzyme that converts androgen to estrogen, thereby feminizing the gonad and the individual.
These data suggest that cultured PGCs are immortalized cells that maintain expression of both surface markers and PGC-specific genes.
The striking conclusion from these findings is that active chromatin modifications and structure are not sufficient to maintain expression of the MHC class I, PD1, gene.
Embryos require Myc protein for growth, and our results show that Su z 2 helps maintain expression of dmyc, providing Myc levels necessary for embryonic growth and proliferation.
Taken together, the results of the above studies suggest that activation of Gs-alpha pathway helps to maintain expression of transcription factors important for pluripotency in ES cells.
In turn, Fgf8 is important to maintain expression of Wnt1 in the early mouse midbrain [29] and Fgf8 beads induce expression of Wnt1 in chick embryos [30].
Several laboratories have reported that 5-aza-dC reactivated promoters exhibit rapid re-silencing [29], [30]; however these experiments could not use selection to maintain expression.
