The findings indicate that the overall cancer RCT system maintains equipoise via unpredictability in the results at any individual trial, while providing the avenue for the researchers to increase their odds to discover new successful treatments which will go beyond 50∶50 odds predicted by the original equipoise hypothesis.
Also discussed is how to establish and maintain equipoise to minimize experimenter bias, strategies for optimal recruitment and retention of potential study participants, measuring and ensuring treatment fidelity, and factors contributing to optimal participant adherence to study participation.
To minimise any distress among pregnant women and maintain equipoise [ 30], oral health promotion material are provided via the dental assistant at recruitment to all trial participants.
This may reflect that alternative effectors such as BIM could preserve equipoise in the conventional T cell compartment.
At a social occasion earlier this year, someone asked Michelle Obama how it was possible for her husband to maintain his equipoise amid so much hatred.
He has a core, and was able to maintain his equipoise, for example, even as his campaign stagnated through the summer and fall.
Enrollment poses challenges in maintaining investigator equipoise, managing conflict of interest and anticipating that patient preferences for specific treatments may reduce enrollment.
Since all biological information has inherent ambiguity, the systematic assessment of information is required by living organisms to maintain self-identity and homeostatic equipoise in confrontation with environmental challenges.
At the same time, scores of smaller muscles in the neck, wrists, hands, and even feet continually fine-tune your efforts, holding the body in constant equipoise in order to maintain the exquisite balance necessary to keep a twenty-four-inch-wide vessel — roughly the width of a man's waist — on an even keel.
Some areas discussed are the role of disease and transplant databases in designing and analysing clinical trials, design options for early-phase trials, maintaining clinical equipoise, eligibility criteria, blinding, outcome measures and statistical analysis, and the composition and role of the data safety and monitoring boards.
