Sentence examples for maintain efficacious from inspiring English sources

Structured singular value analysis determines the volume in parameter space within which the system parameters may exist and still maintain efficacious signaling, but is limited to linear behaviors.

An ideal molecule should maintain efficacious serum levels for approximately 8 10 hours after administration to cover the patient's sleeping period.

The use of vaccines in HIV-infected and HIV-exposed uninfected children raises questions about the capacity of those children to mount and maintain efficacious antibody levels.

Subsequent antimalarial trials conducted in Southeast Asia and Papua New Guinea have continued to demonstrate high rates of P. vivax infection post-treatment, especially when follow-up is continued beyond the period when the antimalarials used are expected to maintain efficacious drug levels in the bloodstream [6], [7].

Overall, our studies suggest that to maintain efficacious levels of therapeutics throughout disease progression adjusting doses of elacridar (or other more potent and selective P-gp/BCRP inhibitors yet to be developed) may be the most valuable solution.

5-chloro-2,4-dihydroxypyridine is a competitive inhibitor of dihydropyrimidine dehydrogenase, which is involved in the degradation of 5-FU, and acts to maintain efficacious concentrations of 5-FU in plasma and tumour tissues (Tatsumi et al, 1987).

This study has concluded that ustekinumab seems to be efficacious for the treatment of moderate to severe psoriasis and that dosing every 12 weeks maintains efficacy for at least a year in most patients.

A 6-mg dose of SC sumatriptan is the most efficacious and fast-acting acute treatment for migraine, but a 3-mg dose of SC sumatriptan may improve tolerability while maintaining efficacy.

Thus, a critical feature of the final molecule is a flat exposure profile that maintains an efficacious dose while minimizing effects on baseline glucose levels.

Moreover, adjustments in tasks or in working hours, different discussion topics during annual progress interviews, taking the private situation of employees into consideration or simply offer a genuine listening ear every now and then may be efficacious to maintain or improve the workability of employees.

Non-invasive time-course measurements may deliver apt information both on the efficacious dose as well as the dosing intervals required to maintain the targeted efficacy using a minimum of experimental animals.