Sentence examples for maintain effector function from inspiring English sources

Nevertheless, BS-mAbs maintain effector function activity when binding their brain target.

These aglycosylated variants have the potential to allow therapeutic antibodies to be produced in virtually any expression system and still maintain effector function.

The results reported here demonstrate that IL-2 signal in the early priming stage not only drove the CD8+ T-cell differentiation but also aid to maintain effector function in vivo.

Thus, the presence of late-differentiated CD8+ T cells exhibiting signs of senescence that are incapable of maintaining effector functions [ 11- 13], and the diversity of T. cruzi antigens that can enter MHC class I processing pathway should be responsible of the absence of a potent and antigen focused cellular immune response [ 8, 14].

Individuals with maintained IFNγ effector function of VZV-specific T cells had lower viral loads and lower disease severity scores.

These T cells are specific to tumor antigens and retain their ability to proliferate, thus maintaining their effector function and homing abilities in vivo [ 10, 14].

Cysteine is important and maintains effector stability in the extracellular space [ 36].

IL-23 is a TH17 cytokine responsible for maintaining the effector functions of TH17 cells.

IL-12 promotes differentiation of CD4+ T cells towards a Th1 phenotype [56] and maintains CD4+ IFN-γ+ IFN-γ+ Tffecell function [57].

An alternative possibility is that the chronic phase of effector function is maintained independently of antigen stimulation, as suggested by experiments in which TCRζdim T cells produce IFN-γ following engagement of costimulatory pathways, while at the same time stimulating monocytes to produce inflammatory cytokines such as TNF through cell contact-dependent pathways.

In murine models Tregs selectively accumulate in the tumor and locally maintain a microenvironment that suppresses the effector function of tumor-infiltrating cytotoxic lymphocytes.