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Exact(10)
Growth factors were not allowed to maintain dose intensity.
The prophylactic use of G-CSF to maintain dose intensity was not permitted.
Growth factor support to maintain dose intensity was administered to 16 patients (73%).
The results reported here indicate the feasibility of this concept by using a sequential approach to maintain dose intensity.
Dose adjustments before the initiation of treatment in this patient group may improve the tolerability of anticancer agents and help maintain dose intensity.
In the majority of cases, G-CSF was given to maintain dose intensity due to haematological toxicity (fourteen patients) or as secondary prophylaxis (four patients).
Similar(50)
These results confirm the importance of tolerable treatment and maintaining dose intensity.
Improved dose individualization and avoidance of or reduction in the severity of toxicity would assist in maintaining dose intensity.
This study further showed that low-dose intensities and treatment discontinuations were correlated with shorter survival times, indicating the importance of maintaining dose intensity.
Previous attempts to use thrombopoietin-stimulating agents have been successful at maintaining dose intensity, although antibody formation limited the use of these agents 24.
The duration of dose interruptions/reductions was relatively short, and most patients who resumed the full 10 mg EVE dose did so within 2 weeks, thereby maintaining dose intensity.
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