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Stratified analysis is required after stratified randomisation to maintain correct type I error rates when (a) there are strong interactions between prognostic factors, and (b) there are approximately equal number of patients in each stratum.
The goals of this paper are (1) to determine whether a stratified analysis is necessary to maintain correct type I error rates after randomisation is performed within each stratum (stratified randomisation), and (2) to compare different methods of adjustment in terms of type I error rate and power, irrespective of the method of randomisation used.
We performed a simulation study based on real datasets to (1) determine whether stratified randomisation is necessary to maintain correct type I error rates after stratified randomisation in real trial scenarios, and (2) to compare different methods of adjustment in terms of type I error rate and power, irrespective of the method of randomisation used.
We performed a simulation study to determine (i) if a stratified analysis is necessary after stratified randomisation to maintain correct type I error rates, and (ii) whether a covariate-adjusted analysis is adequate after minimisation for correct type I error rates (rendering a stratified analysis unnecessary).
Similar(55)
Even in neuronal membranes with relatively few types of ion channels, such as the squid giant axon, the numbers of channels must be tightly controlled to maintain correct firing frequencies in response to synaptic drive.
The DKO mouse was unable to maintain correct posture.
Be able to maintain correct turnout while dancing on flat foot or demi-pointe.
Keep both of your knees very straight and maintain correct posture.
Use the results to target specific organic spreads to maintain correct levels for growing grass.
If you can't maintain correct turnout normally, you will have a lot of trouble maintaining it en pointe, because it's more difficult to maintain turnout then.
IUTA_CQ, but not IUTA_KY, showed the same failure to maintain the correct Type I error rate (results not shown).
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