Sentence examples for maintain chromosomal stability from inspiring English sources

Telomeres are essential to maintain chromosomal stability.

These results provide novel insights into how the FA pathway is intertwined with HHR6 pathway to maintain chromosomal stability and suppress the development of human cancer, representing an important conceptual advance in the field of FA cancer research.

PTTG is the index mammalian securin [30], and both Pttg deletion [31] as well as overexpression [27] result in aneuploidy and chromosomal instability highlighting the requirement for intracellular securin equilibrium to maintain chromosomal stability [32], [33].

These proteins ensure that telomeres behave differently from DSB ends and help maintain chromosomal stability.

Sufficient telomere lengths are required to maintain chromosomal stability and pluripotency of ES/iPS cells (Huang et al., 2011).

To prevent this, we eliminated enzymatic passaging and opted for manual dissection to better maintain chromosomal stability.

Telomeres, consisting of TTAGGG nucleotide repeats and a protein complex at chromosome ends, are critical for maintaining chromosomal stability.

Kif22 plays a role in the organization of spindle microtubules and chromosome movement and regulation of Kif22 activity by CHFR is important for maintaining chromosomal stability [ 27].

BRIP1 functions by maintaining chromosomal stability via its interaction with the C-terminal in BRCA1 [39, 43].

We propose that full activity of Mps1 is essential for maintaining chromosomal stability by allowing resolution of merotelic attachments and to ensure that single kinetochores achieve the strength of checkpoint signaling sufficient to prevent premature anaphase onset and chromosomal instability.

These results indicate that, in response to DNA damage, pol η may act as a functional downstream target of FANCD2 and thus, at least partly, mediate FANCD2 function in maintaining chromosomal stability.