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Telomeres are nucleoprotein structures present at the ends of chromosomes that help maintain chromosomal integrity.
Telomeres cap chromosomal ends and help to maintain chromosomal integrity.
Appropriate levels of B-Myb are required to maintain chromosomal integrity and cellular euploidy, and any dysregulation in the expression or function of B-Myb promotes differentiation and/or aneuploidy that can result in apoptosis (Figure 7).
HR is a process predominantly exploited by lower organisms, whereas both HR and NHEJ concur to maintain chromosomal integrity in eukaryotes.
The prior existence of this and other epigenetic systems to maintain chromosomal integrity may be the reason that transposons are tolerated and abundant in eukaryotic genomes (Federoff 2012).
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Telomeres consist of long (TTAGGG n nucleotide repeats and an ordered protein complex at the ends of chromosomes that are essential to maintaining chromosomal integrity [ 1].
Telomeres, the linear ends of eukaryotic chromosomes, consist of specialized tandem (TTAGGG n DNA repeats and associated telomeric binding proteins that serve to protect the ends of chromosomes from recombination, end-to-end fusion and degradation, thereby maintaining chromosomal integrity (Blackburn 1991).
These fulfill important functions for maintaining chromosomal integrity.
PTEN also plays a role in maintaining chromosomal integrity [ 17].
Three of these proteins, Sir4, Zds2, and Dun1, are involved in maintaining chromosomal integrity and promoting DNA repair.
Heterochromatin and its associated histone modifications are important for repressing transcription and maintaining chromosomal integrity during meiosis and mitosis.
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