Sentence examples for maintain chromatin integrity from inspiring English sources

We discuss the importance of this H3.3 deposition as a salvage pathway to maintain chromatin integrity.

H3.3 is found decorated with various histone modifications that regulate transcription and maintain chromatin integrity.

The cell engages different co-transcriptional mechanisms to maintain chromatin integrity over transcribed genes.

It has been suggested that polyadenylated histone variants are required in these non-replicating cells to maintain chromatin integrity [ 7, 39].

Therefore, the protein encoded by this histone gene may function to maintain chromatin integrity in immature neurons or might be involved with transcription or DNA repair.

This evidently requires some mechanism for maintaining chromatin integrity.

As shown in Figure 5, with the exception of H3-L61F, all other H3-L61X mutants display a range of Spt− phenotypes, thus underscoring the importance of L61 of histone H3 in maintaining chromatin integrity.

This highlights the potential importance of histone H1 in maintaining chromatin integrity, and suggests two possible functions of H1 variants: a general one redundant among H1 variants and related to the formation of higher order chromatin, and an individual, gene-specific one.

A role of H3K36me3 in maintaining chromatin integrity was recently disclosed by the finding that the DNA mismatch repair (MMR) protein MutSα binds H3K36me3 and that SETD2 is necessary for human DNA MMR, a mechanism that corrects mismatches generated during DNA replication (Li et al., 2013).

Certainly, colloidal centrifugation selects spermatozoa with intact and mature chromatin, which have a higher density than immature or damaged sperm [ 19- 21]; further, the removal of damaged or dead spermatozoa and leukocytes may help maintain sperm chromatin integrity by preventing future damage caused by reactive oxygen species (ROS) [ 10, 19, 20].

Given the role of histone acetylation in promoter chromatin remodeling, leading to transcription initiation, it can be concluded that the Set2/Rpd3S pathway ensures post-transcriptional chromatin integrity by maintaining nucleosomes over the coding regions in a hypoacetylated state.