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The cells could maintain cell division beyond 3 months with sustainable hepatocyte function suitable for drug screening.
The concept of synthetic lethality is based on the reliance of cancer cells on DNA repair to maintain cell division.
Possibly, young tissues as those sampled for the libraries were all overrepresented with regard to protein and amino acid metabolism, since both are required to maintain cell division and multiplication typical of young tissues.
This could be because very few cells in the total population retain the ability to maintain cell division cycles, which could eventually result in non-detectable colonies of cells.
As transformed cells, the PC12 line has an advantage over cultured primary neurons, which do not maintain cell division and thus cannot detect adverse effects on the cell cycle, a likely neurotoxic target.
As transformed cells, the PC12 line has an advantage over cultured primary neurons, which do not maintain cell division and thus cannot detect adverse effects on the cell cycle, a likely neurotoxic target; furthermore, primary neurons do not provide a uniform population either in terms of cell types or differentiation state, rendering their use for screening problematic.
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RSS1 plays a role in maintaining cell division in meristematic zones under salt stress conditions, likely by interfering with the cytokinin response pathway.
The AtWOX9 gene is involved in maintaining cell division and preventing premature differentiation in the Arabidopsis SAM [ 19].
In this context it is interesting to note that, similar to FAF overexpression, loss of STIP function can be compensated for by exogenous sucrose, which is in agreement with the proposed function for STIP in maintaining cell division.
This globular polymer functions to maintain cell shape, division, migration, junction formation, and intracellular vesicle trafficking [ 26].
Centrosomes are the major microtubule (MT) organizing centers (MTOCs) in many eukaryotic cells and they play an important part in many cell processes, including establishing and maintaining cell polarity and cell division (Bornens, 2012; Nigg and Raff, 2009).
More suggestions(15)
retains cell division
sustains cell division
maintain cell integrity
maintain cell permeability
maintain cell wall/cell
maintain cell cycle
maintain cell wall
maintain cell survival
maintain cell redox
maintain cell specificity for
maintain cell pluripotency
maintain cell morphology
maintain cell phone
maintain cell homeostasis
maintain cell membrane
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