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Homeostasis postulates constancy of physiological functions to maintain basic functions of the organism.
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A collection of genes are expressed in all tissues/cells to maintain basic cellular functions, traditionally known as housekeeping (HK) genes, whereas others are specialized to perform unique functions in differentiated tissues/cells, known as tissue-specific (TS) genes.
A generally accepted view of gene expression programs divides genes in two main categories: i) housekeeping genes that are virtually always expressed in every tissue and work to maintain basic cellular functions; and ii) genes whose expression is preferential in one or a few tissues and which provide specialized functions that have a strong effect on the physiology of the whole organism.
The body may be using a massive shell/core response to maintain basic life functions.
A person's weight remains stable as long as the number of calories consumed doesn't exceed the amount of calories the body spends, both on exercise and to maintain basic body functions.
They're byproducts of normal cell activity, and without them, oxygen couldn't react with other molecules to maintain basic biological functions.
The lack of major phenotypes upon G6PD knockdown indicated that the residual G6PD activity in Gi C. elegans is sufficient to maintain basic cell functions in C. elegans.
In contrast, genes with a wide spectrum of expression are presumed to maintain basic cellular functions irrespective of the tissue type.
This may be due to the fact that genes required to maintain basic cellular functions may be regulated by other biological factors such as DNA methylation.
Using this construction model, we note that every tissue-specific network inherits a shared core of interactions among housekeeping genes that are universally expressed to maintain basic cellular functions.
The so-called 'death zone' of Mount Everest is a liminal space; a change in weather could make the difference between a survivable mountaintop and a site where the human respiratory system cannot maintain basic biological functions.
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