Sentence examples for maintain an epithelial from inspiring English sources

These cells maintain an epithelial phenotype and can be manipulated experimentally for several passages before cellular senescence.

These miRNAs have been proposed to maintain an epithelial phenotype in some cells and their decline in response to Zeb-1 commits the cells to transition to a mesenchymal phenotype [ 51- 54].

The demonstration that overexpression of ESRP1 was able to block the splicing switch and maintain an epithelial phenotype raises the question of whether upregulating ESRP1 levels in mesenchymal cells could restore an epithelial phenotype.

(27) These miRNA serve to maintain an epithelial phenotype and protect against EMT through repression of multiple targets, including the EMT-inducing transcription factors (ZEB1 and ZEB2); genes involved in migration (FN1, MSN and WAVE3); and epigenetic regulators (SIRT1 and Suz12).

Given that down-regulation of ERβ1 has been observed in invasive breast cancers, in this study we hypothesized that ERβ1 functions to maintain an epithelial phenotype in breast cancer and examined whether ERβ1 reduces the invasiveness of basal cancer cells by repressing EMT [ 26].

TGF-α and/or HA treated cells showed comparable cell cell adhesion whilst maintaining an epithelial cell phenotype.

TGF β signaling is regulated by cytoplasmic kinases (Bone Morphogenic Proteins – not discussed herein), Retinoic Acid-Retinoic Acid Receptor (RAR) and is important in developmental programs and maintaining an epithelial state.

This maintains an epithelial sheet with roughly isotropic polygonal cells.

However a dramatic inhibition of cardiac EMT resulting in the majority of cells maintaining an epithelial phenotype (rounded and non-invasive) was observed with WNT16 sequestration (Fig. 4B; gel surface image).

Primary murine AECs cultured on laminin maintained an epithelial phenotype [ 24].

Initially Pax3 is expressed throughout the epithelial somite and then becomes restricted to the dorsal domain, the dermomyotome, which maintains an epithelial structure.