Sentence examples for maintain affinity from inspiring English sources
Model ester prodrugs using the stabilized dipeptides d-Glu Ala and-Glu Alalands pro-moieties for benzyl alcohol have been shown to maintain affinity for hPepT1.
Specific structural modifications were performed in order to maintain affinity for the target receptor and to improve the selectivity over 5-HT1A adrenergicrgic α1 receptors.
Presumably, flexibility in the resulting contact allows the N255K mutant to maintain affinity for microtubules even when the switch loops are open.
Avoiding deleterious effects of the substitutions, we successfully engineered a protein A variant that exhibited high pH sensitivity and maintained affinity, thermal stability, and alkaline tolerance.
The engineered BMP2 variant L51P is deficient in BMP receptor type I activation but maintains affinity for BMP antagonists and can allow for the inactivation of BMP antagonists, and eventually enhance BMP2 action.
As found in our previous research [8], replacement of chlorine atoms with methyl substituents maintained affinity for D2Rs at the same level.
We demonstrate that the described CID maintains affinity for Bcl-2 both in vitro and in cellular assays.
Mutations of the cysteine to serine or alanine have been shown to abrogate all enzyme activity while maintaining affinity for substrates in vitro, a feature that is used to obtain PTPs in complex with phosphotyrosine substrates (mutant trapping) [ 28].
Figure 5 shows that reducing the affinity of trastuzumab to the soluble HER2 receptor by 100-fold while maintaining affinity at the membrane-bound receptor results in higher plasma concentration, more free ECDHER2 in the interstitial space, and higher receptor occupancy at the membrane-bound receptor even in the presence of high levels of soluble ECDHER2 of 878 ng/ml in plasma.
This initial SAR suggests pharmacophoric elements that may be modified to modulate/increase opioid affinity, while maintaining high affinity for the NOP receptor, to result in potent bifunctional small-molecule NOP/MOP ligands.
The high-affinity sequences maintained an affinity for phosphorylated PhoP higher than that of the lower-affinity sequences.
