Indeed, it can be used, to a various degree, for sperm hyperactivation and, therefore, for gamete motility, for protein phosphorylation, for sperm structural changes, for maintaining adequate concentrations of intracellular ions, and in this respect mainly Ca++ ions, and eventually for the synthesis of new molecules.
Results from the pivotal study suggested that paediatric patients might require higher infliximab doses than adults on a mg/kg basis to maintain adequate serum concentrations and minimise the development of antibodies to infliximab and related infusion reactions.
Indirect confirmation was the slightly increased total IRS-1, suggesting the cell's attempt to maintain adequate total concentrations of IRS-1 which could be activated or inactivated in response to specific stimuli.
Therefore methods like endothelial gene transfection/transfer in vivo may effectively maintain adequate IL-10 concentrations near the endothelial cells that finally achieve the protection against cytokines that is not uniformly produced by systemic IL-10 administration.
This is supported by the finding that overexpression of PGC-1α counteracted the inhibitory effect of DOCA-salt on expression of GTPCH1 and DHFR, indicating PGC-1α maintain adequate intracellular BH4 concentration by increasing the expression of GTPCH1 and DHFR.
Concentrations of quercetin were increased to 100 μM because instability of quercetin in media necessitated higher initial loading to maintain adequate cellular and media concentrations for uptake and metabolism of the flavonol.
Insulin concentration increases after a meal, and is instrumental in maintaining adequate glucose concentrations.
The airway pressures and oxygen concentrations required to maintain adequate blood gases are often very high in patients with severe respiratory failure, and this combination of barotrauma, volutrauma and oxygen toxicity can prevent lung recovery.
Our findings provide the first high quality evidence from a randomised controlled trial for the development of universal guidelines and support the British Thoracic Society's recent guidelines on acute oxygen treatment, which recommend that oxygen should be administered only at concentrations sufficient to maintain adequate oxygen saturations.
The in vitro drug release profile of the DDS was studied using high performance liquid chromatography, which confirmed that the DDS released CsA at a stable rate and maintained adequate CsA concentrations for a relatively long time.
