Sentence examples for maintain a stem from inspiring English sources

Considering these observations, we sought to elucidate whether CD95 signaling might also activate or maintain a stem cell-like and EMT-programmed population of cells in GBM.

Sox1, Sox2 or Sox3 maintain a stem cell-like state [49], [50], and Sox9 alters the potential of stem cells from neurogenic to gliogenic [51], whereas Sox10 is essential for terminal oligodendrocyte differentiation [52].

As in conditions favoring proliferation FasL induces ERK1/2 activation, and BM MSCs maintain a stem cell phenotype through ERK1/2-dependent mechanisms, we explored ERK1/2 activation in BM MSCs treated with 0.5 ng/ml FasL.

Stem cells are capable of renewing themselves to maintain a stem cell pool as a preserved cell source for tissue homeostasis, while they can also differentiate into mature cells to carry out the function of a specific tissue.

These data demonstrate that GSCs are capable of utilizing different modes of cell division to maintain a stem cell population and GSCs are maintained mainly by symmetric, not by asymmetric cell divisions.

It is possible that these observations reflect a decreased ratio of muscularis mucosa to epithelium in benign lesions, but a tendency for malignancies to acquire their own Gremlin expression and perhaps a mesenchyme-like phenotype in order to maintain a stem cell-like state independent of the surrounding tissues.

This is a novel finding, as Cx43 has not been previously linked to this master regulator of genes required to maintain a stem-like phenotype.

Our NGS results suggested that Ap4 is involved in maintaining a stem cell-like expression pattern in tumor cells.

Since lncRNAs have the capacity to precisely control the cellular epigenetic and transcriptional landscape30, this core ncRNA signature may be essential for establishing and maintaining a stem cell-like state.

Upregulation of EZH2 expression in tumors appears to correlate with disease progression by maintaining a stem cell-like phenotype.

Asymmetric cell divisions are a major route for stem cells to give rise to differentiated cells while simultaneously maintaining a stem cell population.