Sentence examples for maintain a proliferative from inspiring English sources

Furthermore, the majority of these cells expressed Ki67 on all three matrices, indicating that these CMs maintain a proliferative potential.

They exhibit two distinct properties: self-renewal, the ability to maintain a proliferative state without changes in cellular characteristics; and pluripotency, the capacity to generate all of the cell types of adult organisms.

Recently, miR-126-5p is found to maintain a proliferative reserve in ECs through suppression of the Notch1 inhibitor delta-like 1 homolog (Dlk1) and prevents atherosclerotic lesion formation in ApoE−/− mice [ 17].

In addition, xenograft HSA tumors showed positive immunolabeling for VEGF-A, bFGF, flt-1, and flk-1, similar to the original tumors; thus, those xenograft models maintain a proliferative mechanism similar to that found in spontaneous canine HSA.

In many types of cancers, including glioma, prostate cancer and breast cancer, Akt is required to maintain a proliferative state and for progression into a more malignant state in conjunction with genetic mutations.

The current report of SCD-1 induction in response to 17β-ED may represent a particularity of ERα + ve breast carcinoma cells that necessitate estrogen for optimal growth, which includes metabolic changes to assure a supply of unsaturated fatty acids for appropriate membrane biogenesis required to maintain a proliferative state.

In the presence of ATc, the mutant parasites maintained a proliferative phenotype.

Genes expressed in basal cells are involved in maintaining a proliferative undifferentiated phenotype and promote cell survival.

Interestingly, overexpression of Gata2, Lmo2, Mycn, Pitx2, Sox17, and Tal1 in mPSCs established and subsequently maintained a proliferative state with hemangioblast potential (Vereide et al, 2014).

In head and neck squamous cell carcinoma where SIRT3 is overexpressed, SIRT3 can maintain ROS levels at the appropriate levels for maintaining a proliferative and aggressive phenotype, thus preventing apoptosis and promoting carcinogenesis.

This finding suggests that CLL cells are not simply seed in a supportive soil but instead are actively involved in a complex crosstalk that possibly will maintains a proliferative behavior.