Sentence examples for maintain a differentiated from inspiring English sources

The requirement for continuous regulation to maintain a differentiated phenotype was postulated previously.

Therefore, in order to reinforce the concept that saffron-derived compounds maintain a differentiated state of prostate cancer cells, we analyzed the immunohistochemistry expression of proteases involved in the migratory and invasive properties of PCa.

For example, sinusoidal endothelial cells were able to maintain a differentiated phenotype when cultured on ECM derived from the liver but not on ECM derived from the small intestine or bladder [ 4].

Although ESCs can tolerate DNA hypomethylation without impairment of cell proliferation (Tsumura et al., 2006), hypomethylation nonetheless impairs the capability of ESCs to achieve, and maintain a differentiated state (Feldman et al., 2006; Jackson et al., 2004; Sinkkonen et al., 2008).

We propose two linked hypotheses: first, when Ptf1a is lost from individual cells, other acinar-specific transcription factors that prevent reprogramming and co-regulate PTF1 target genes, such as NR5A2 and BHLHA15/MIST1, are sufficient to maintain a differentiated phenotype over the short term.

These differentiated GBM cells were then subjected or not to a 3-Gy irradiation and placed 2 days after in either FCS or stem cell medium (SCM), in order to maintain a differentiated status or to favor a possible reversion to a stem phenotype, respectively.

These results suggest that a normal level of serotonin is critical for maintaining a differentiated brain response to threatening face emotions.

The use of biodegradable microcarriers as initial supports for tissue engineering has been demonstrated to be advantageous for maintaining a differentiated cell phenotype; the high surface area also allows rapid cell expansion.

We conclude that the miR-143/145 gene is necessary for maintaining a differentiated SMC phenotype in the adult.

Second, they proved that HOXD10, a homeobox transcription factor that promotes or maintains a differentiated phenotype in epithelial cells, is a target of miR-10b.

Explants of tracheas from hamsters were cultured in either a chemically defined minimal essential medium, which maintains a differentiated epithelium, or a nutritionally complex medium, which encourages the development of squamous metaplasia.