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"Marijuana legalization has gone from an abstract concept to a mainstream issue to a political reality within a three-year period".
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It wasn't really a mainstream issue at the time -- and I remember thinking that while the criticism was no doubt appropriate, it seemed to me to be a distraction from more pressing issues facing American Indians in Minnesota.
But unlike her predecessor, Ms Harman eschewed jokes in favour of a focus on issues affecting family life, implicitly suggesting that they had become mainstream issues appealing to middle England.
As Senator John Edwards, a centrist North Carolina Democrat put it, "Mainstream issues are going to be the big issues that are brought to the floor".
Potočnik called for resource use to become a "mainstream" issue in economics.
With gasoline at $3 a gallon and climbing, geopolitics continually threatening to roil the markets, and environmentalism poised to become a more mainstream issue, Tesla could be driving into a perfect storm.
It seemed very strange for me that what I had decided to do privately was now a mainstream issue.
This topic is a mainstream issue in the field of ecological economics, but its application to fisheries is rather unexplored, even though fisheries have been the focus of many pioneering studies related to natural resource management.
It's my mission to ensure that banning FGM becomes a mainstream issue.
He also almost single-handedly made the CIA drone program and drone strikes on Americans overseas a mainstream issue when he spent nearly 13 hours on the Senate floor talking about the issue to a rapt cable audience.
Given the number of people with criminal records this is now a mainstream issue for all recruiters, but it can often seem difficult and complex to act upon.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com