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Although this technique is promising, further investigation is needed to test its robustness in assessing patients in mainstream clinical practice.
Following the landmark approvals by the United States Food and Drug Administration, the adoptive transfer of CD19-directed chimeric antigen receptor (CAR) T-cells has now entered mainstream clinical practice for patients with chemotherapy-resistant or refractory B-cell malignancies.
BCP provides a rapid and flexible alternative to gene-based susceptibility testing methods for S. aureus, and should be readily adaptable to different antibiotics and bacterial species as new mechanisms of resistance or multidrug-resistant pathogens evolve and appear in mainstream clinical practice.
Given the significant burden of EBV-associated tumors worldwide, important future goals of this adoptive T cell therapy are the introduction into mainstream clinical practice and the extension to EBV-associated tumor entities other than PTLD [21], [40].
However, these techniques have not entered into mainstream clinical practice around the world.
The challenge currently facing neuroimaging in this field is to translate these findings into mainstream clinical practice.
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Unfortunately, there has been a reluctance to translate the lessons learnt in academic settings into the mainstream of clinical practice.
It will take time and effort for these guidelines to be mainstreamed into clinical practice.
Pilots found a low level of awareness of genetics services and of the application of genetics to clinical practice in mainstream specialties and primary care (Table 2).
However, these techniques have not been widely used to date in clinical practice as a mainstream oncology application.
Objective and subjective scales estimating improvement in both clinical studies and clinical practice are becoming more mainstream.
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mainstream clinical opinion
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mainstream political practice
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