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Previous studies that validated medication proxies for the identification of children with asthma mainly validated proxies applicable in etiological research and focused on PPVs.
To date, its predictive power was mainly validated in the context of school outcomes: attainment and grades.
The test was mainly validated in systemically untreated patients with estrogen-receptor (ER) positive and negative invasive breast cancer, <55 or 60 years, with no axillary nodal involvement.
Another limitation of this study is that our results, the highly connected modules of gene lists, were mainly validated through speculative discussions based on literature.
Except for de Hoon et al. [ 10, 11, 21], which focused on B. subtilis, these methods were mainly validated using information from E. coli.
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The results mainly validate our whole element comparison (see Additional files 4, 5, and 6 for results from the reverse transcriptase, integrase and protease domain, respectively).
However, inventories which capture the 'Sense of Coherence' (SOC) based on Antonovsky's concept of salutogenesis have mainly been validated in psychosomatic and psychiatric patients [ 6, 8].
SOC is important because of its potential prognostic relevance in cancer patients, but the current SOC scale has mainly been validated for psychiatric and psychosomatic patients.
Different prediction models for the evolution within a small population of the genetic mean of a selected trait, its genetic variance and its inbreeding have been developed but have mainly been validated through Monte Carlo simulation studies.
However, the HRQoL questionnaire used was constructed for, and has mainly been validated in, cancer patients and might not be an ideal measurement to assess HRQoL in people with cardiovascular disease.
Transgenic HD51 CAG rats were used also by other research groups, mainly to validate changes in their behaviour, which indicates impaired striatal function (e.g., [ 9, 21– 21]).
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CEO of Professional Science Editing for Scientists @ prosciediting.com