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After primary infection, HTLV presents a low level of productive replication, and the proviral genome is mainly replicated through oligoclonal expansion of infected cells, a fact that contrasts with the high rate of de novo cell infection seen during chronic HIV disease [ 185, 194– 194].
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During systemic dissemination L. monocytogenes mainly replicates within cells of the spleen and the liver.
E. tenella mainly replicates in the epithelium of the cecae, but developing stages of E. tenella have been found in the bursa of Fabricius [ 13], also involved in replication of IBDV [ 20].
Once HIV has crossed the genital epithelial barrier the virus mainly replicates in submucosal CD4+ T cells and the infection is then further spread to regional lymphnodes and the systemic circulation.
CD4-CD8+ are MHC class I restricted and mainly recognize replicating viral antigens.
As proven by this work, method transfer is readily possible mainly by replicating method parameters on the automated system.
During the preparation phase agreements on study conditions and logistics were achieved, while the training phase focused mainly on replicating test procedures and judgment.
All four viruses examined replicated mainly in the lungs without evidence of systemic infection.
Also, none of the obtained data contain exactly the same values even in the replicated samples, mainly due to high biological variation among samples.
During the simulation, mainly each of the replicated configurations will evolve independently according the underlying MCMC scheme charaterized by the weight Eq. (7) at its current temperature, i.e. according to Eq. (8).
This study also indicates that PCV1 and PCV2 have different cell tropism during foetal life, since PCV2 replicates mainly in the cardiomyocytes and macrophages of the heart tissue [ 26] and PCV1 targets mainly the epithelial cells of the lungs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com