Human C1-esterase inhibitor (C1-INH) is a multifunctional plasma protein with a wide range of inhibitory and non-inhibitory properties, mainly recognized as a key down-regulator of the complement and contact cascades.
Although PCs are mainly recognized as the outer leaflet lipid, it should be remembered that some part of this lipid species are present also in the inner leaflet (∼15% of the total inner leaflet lipids depending on the membrane).
The present study demonstrates that profilin-1 is highly expressed in human atherosclerotic plaques, and – although mainly recognized as an intracellular actin-binding protein – serves as an extracellular ligand and induces atherogenic effects in VSMCs such as DNA synthesis and migration.
This increase in the incidence of TC is mainly recognized as an increased detection of papillary thyroid microcarcinoma (PTMC) [ 6].
In addition, autoregressive fractionally integrated moving average (ARFIMA), which is mainly recognized as a parametric method suitable for long memory processes where the decay is slower than in an exponential process [24], is included for comparison as well.
