Unfortunately, the limited repertoire of particles (mainly pathogens) that can be internalized by non-professional phagocytes restricts the type of studies that can be done in these cells.
However, it is also true that they do not distribute evenly across the taxonomy, and some clades are highly homogeneous and composed mainly of pathogens or mainly of avirulent strains (see Supplementary Fig. S1 online).
Finally, group G (remaining Rickettsiales), composed mainly of pathogens, has few of the factors involved in Caulobacter cell cycle progression regulation.
While Helicobacter pylori strains where HpyAV and the putative HpyPORF28P and HpyGORF49P R-M systems reside, are the etiological agent of common gastritis and a risk factor for gastric cancer, Campylobacter upsaliensis, Yersinia kristensenii and Vibrionales bacterium are mainly zoonotic but opportunistic pathogens of humans.
The genus Campylobacter contains two important pathogens of animals affecting mainly the reproductive and gastrointestinal tracts [ 1].
NM10 (Table 1) consists mainly of obligate pathogens that are distributed across three mountains on the phylogenetic map, PM05, PM07, and PM09 (Table S1) that encompass four different orders including members of the Firmicutes, Gammaproteobacteria, Nanoarchaeota, and Spirochaetes.
Viroids are important pathogens of plants.
Viruses are important pathogens of livestock.
Typically, bacterial pathogens of plants are intercellular.
We focus mainly on pathogen diversity (as numbers of species) rather than on the effects of disease that they impose, noting that many diseases, e.g., infant diarrhea, can be caused by more than one species of pathogen.
