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Actual data are based mainly on expert's opinions, except one national registry study.
Secondly, the method relies mainly on expert elicitation for both experts in modelling and energy economics.
Other reasons for the heterogeneity in MOH management are the shortage of controlled treatment studies, meaning that treatment recommendations are based mainly on expert opinions rather than on solid scientific evidence [20], and the fact that MOH is, in many respects, a heterogeneous disorder.
In clinical sepsis, recent guidelines - based mainly on expert opinions (Surviving Sepsis Campaign) - have recommended fluid administration to restore cardiac filling pressures to at least 12 mmHg during mechanical ventilation [ 19].
'Directive' policies are based mainly on expert opinion and seek to build peripheral capacity through education, training, employment opportunities and participation in peripheral networks, although mainly central resources are provisioned, and central, quantitative monitoring makes adaptations difficult.
Current guidelines are based mainly on expert opinion and small studies rather than on well conducted clinical trials, leading to wide inter-centre variability in dosing recommendations [ 2, 21, 22].
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However, this statement is mainly based on expert opinion, because only one experimental study has addressed this matter in detail to date (Noris et al, 2009).
We mainly depended on one expert in the study, though a few other researchers later participated in the review of the gold standard; ideally, at least 3 experts working independently would be desirable.
Qualitative risk assessment is mainly based on expert knowledge, whereas quantitative risk assessment uses mathematical methods (Bühlmann 1996).
So far this knowledge is incomplete and mainly based on expert opinions (Meyer et al. 2003; Rock et al. 2008; Zell et al. 2009).
Methods that mainly rely on expert elicitation, such as the NUSAP method might lack reproducibility of results and objectiveness (requirements 2 and 6).
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