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Neurotoxicity, a potential concern because of the weekly oxaliplatin administration, consisted mainly of grade 1 events.
The therapy was generally well tolerated; the observed adverse events were mainly of grade 1 2 severity.
Nausea/vomiting was mainly of grade 1 or 2, with 10% of patients reporting grade 3 episodes.
Toxicity was acceptable: side-effects consisted mainly of grade II National Cancer Institute common toxicity criteria (NCICTC) leucopenia and thrombocytopenia in ten patients.
Acute radiation related side effects were mainly of grade 1 or 2 in skin, oral mucosa, salivary glands, and pharynx-esophagus.
In both settings, the majority of adverse drug reactions were mild/moderate and consisted mainly of grade 1/2 diarrhoea and skin rash.
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Comparison of molecular and pathological classification highlighted that a tumour group 1 (gene expression cluster 1, Figure 1) was mainly consisted of grade 3 carcinomas (tumours no: 36, 89, 12 and 51) and one grade 2 carcinoma (tumour no.
Treatment was delayed for a median of 6 days (range: 4 28) in 70 cycles (18.2%) in 43 patients (82.7%), mainly because of grade 2 4 neutropenia (11 cycles), infection without neutropenia (10 cycles), grade 2 stomatitis (7 cycles), febrile neutropenia/infection with neutropenia (5 cycles), and abnormal liver function test (5 cycles).
The expected side effects were mainly of low grade.
The BRCA1 methylated tumours were mainly of tumour grade 3 (7/13) and infiltrating ductal type (12/13).
Most patients presenting at the clinic complained mainly of high grade fever (39 - 40 °C), abdominal pain at the upper right quadrant area and malaise.
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