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The most demanding requirement is that each agent should always have a dominant strategy, but mainly negative results are obtained in this case.
Chinese researchers who used CRISPR to experiment for the first time on a human embryo in April 2015 made their (mainly negative) results public, a decision that was described as 'ethical' and 'could reduce both risky and pointless research' (Sandberg 2015).
DJ-1 alterations are more frequent than α-syn mutations; consequently, DJ-1 has been evaluated as a genetic predisposing factor for sporadic PD though with mainly negative results [23], [24].
There were conflicting but mainly negative results regarding the influence of baseline pain severity, neurological deficit, nerve root tension signs, duration of symptoms and radiological findings on outcome.
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The debate regarding safety of supplementation of immune-modulating nutrients has mainly emerged from negative results of the REDOXs [9] and OMEGA [10] trials with, respectively, 80 and 85% medical ICU patients, while in the SIGNET trial [8], showing no benefit nor harm of immune-modulating nutrients, only 25% of included patients were medical.
However, validation of the methods proposed here is required by applying them to a larger sample of individuals from different populations and geographic origins in order to avoid mainly false-negative results.
Several meta-analyses on the efficacy of TENS in painful disorders have yielded ambiguous or negative results mainly due to inadequate methodology and/or reporting [143, 145 148].
One of the major limiting factors of the present study is small sample size, which could condition false negative results (mainly the negative results in the cross sectional study) [ 24].
It was concluded that a substantial rejuvenation of the estuary was possible utilising various strategies, including creating a tidal lake, removing tidal levees, reconstituting an old meander system, and creating an additional waterway, whilst mainly negative trade-offs would result from installation of a barrage.
We experienced an overall sensitivity of 73% and specificity of 38%, the false negative results being mainly small size (<10 mm) infiltrating malignant lesions and ductal carcinoma in situ (DCIS).
A change of policy was shown, mainly due to the decrease of false negative results.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com