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Although well established in cell lines and today frequently used in transgenic mouse strains, certain limitations apply to these systems, mainly insufficient tightness of gene-repression and/or moderate induction levels, e.g., due to ineffective delivery and targeting of agonists to the cell type/tissue of interest, as well as stochastic epigenetic transgene silencing [4] [5].
Moreover, data on psychometric properties are mainly insufficient; for an overview of IADL scales in dementia where the need for validation studies is explicated, see the article by Sikkes et al. [ 83].
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Uncertainty in the outcomes of fire-smart management arises mainly from insufficient understanding of the relative weights of fuel and weather-drought on the fire regime.
This is related mainly to insufficient access to prevention methods, HIV screening and antiretroviral treatment (ART) in developing countries.
Vitamin D deficiency is a global health problem caused mainly by insufficient exposure to sunlight.
Furthermore, Stöhr et al., in a series of 30 patients, described a 40% need for primary veno-arterial cannulation in patients suffering from ARDS and an additional need for a change of configuration in 11 patients, mainly for insufficient oxygenation [ 25].
The non-accurate results for the small parties caused mainly due to insufficient number of samples.
The limitations of LBS are related mainly to the insufficient precision of position estimation.
However, information about their levels is still insufficient, mainly in marine biota.
This may be mainly due to insufficient data that would guide such recommendations.
The project delay is mainly caused by insufficient design, procurement delays, production delays and bad management.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com