In contrast, the under-abundant proteins were mainly implicated in transport, TCA cycle and respiration.
Stimulation of postsynaptic 5HT1A and 5HT2A receptors has been mainly implicated in the development of the syndrome.
It has been suggested that GlyT2 is mainly implicated in the control of inhibitory neurotransmission via GlyRs, whereas GlyT1 is considered to regulate the glycine level in both inhibitory neuron and excitatory neurons [4 8].
Immediate early gene Arc expression was determined by immunohistochemistry to show if prefrontal cortices (PFC) and hippocampi were activated following RAM training as these regions are known to be mainly implicated in spatial memory.
Concerning the mnemonic accumulator hypothesis, a review of the literature showed evidence that the intraparietal sulcus was mainly implicated [28].
In addition, the human MSY contains multicopy genes with ∼60 transcription units in ampliconic regions, encoding 9 different proteins mainly implicated in sperm production [5], [8].
Thus far, the p24 proteins have been mainly implicated in the selection and packaging of secretory cargo proteins (cargo receptor model; reviewed in [2]).
However, it has been suggested that Top2β is mainly implicated in the induction of DSB, while Top2α is essential for citotoxicity [30].
IL-2 and IFN-γ secretion is representative of the TH1 profile, mainly implicated in cellular immune responses, whereas IL-4 and IL-10 secretion is associated with the TH2 profile, mainly implicated in the humoral immune response and/or negative regulation of the immune response [23].
In spite of their similarities, they play different roles in nuclear processes, being Top2α mainly implicated in DNA relaxation/decatenation and segregation [7] and Top2β mostly associated to transcription [8], [9].
