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Both EMA and G-BA requested mainly efficacy and safety data (44/54 and 23/35 categories requested, respectively); however, 28/35 G-BA data requirements went beyond requests made by the EMA.
In contrast to clinical trials concerning mainly efficacy and safety aspects, the primary goal of this study was the comprehensive evaluation of preferably all relevant aspects of treatment quality from the patients' perspective such as effectiveness, quality of life and further treatment options.
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However, final cost-effectiveness will depend mainly on efficacy data of PCV13 confirmed by clinical trials, particularly in inpatient CAP.
Clinical questions were asked most often (65.9%), mainly including efficacy (33.2%) and safety questions (24.0%).
The EMEA guidelines for psychiatric conditions (mainly for efficacy) will need to be revised with specific paediatric considerations.
Few studies had strong evidence, mainly evaluating efficacy in switching from anti-TNFα to new targeted therapies (rituximab, abatacept, and tocilizumab).
The factors associated with women's decisions to seek timely care can be hypothesized at various levels; the women's level, mainly her efficacy in making such a decision, care provider level based on the provider's competency and availability of these services, and the policy environment which determines how, where and when these services are delivered and by whom.
Inspired by this perspective, in this article, we conducted a meta-analysis of the literature on (largely quasi) experimental intervention studies (N = 47, with 49 independent samples) aimed at enhancing mainly self-efficacy and self-confidence in order to influence a range of academic outcomes in university students (N = 5771).
These are mainly the vaccine efficacy parameters, together with the age-specific incidence rate of diarrhoea.
The design of the blankets mainly determines the efficacy of a forced-air warming system.
Antitumour treatments are thought to exert their therapeutic efficacy mainly by induction of apoptosis in tumour cells.
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CEO of Professional Science Editing for Scientists @ prosciediting.com