Sentence examples for mainly deleterious from inspiring English sources

In rodents, CR has been described as beneficial for cognitive performances in mice [12], [39] and mainly deleterious in rats [13], [14].

Dobzhansky, in his book entitled "Genetics and the origin of species" (Third edition 1951), pointed out the existence of an apparent paradox from the studies on genetic variability in natural populations: The majority of genetic variants that are retained in heterozygous condition are mainly deleterious and then cannot be seen as useful elements for evolutionary processes.

Most of the mutations will be deleterious.

It evokes unpleasant images, and is always deleterious.

Let all mutations be deleterious.

If inbreeding depression is mainly caused by deleterious mutations having a strong effect, selection may rapidly eliminate deleterious alleles, and population fitness rebounds (Wang et al. 1999; Wang 2000) while the inbreeding levels of populations are reduced (Moore 2007).

In other words, it remains unclear whether GLAP could mainly mediate the deleterious effects of Gly-AGEs on HUVECs.

In the Ohta domain (Ohta 1973), patterns of molecular evolution are driven mainly by slightly deleterious mutations (Gillespie 1999).

One of the prevailing ideas posits that DNA methylation evolved mainly to suppress deleterious transpositions of repetitive elements (Yoder et al. 1997).

However, none of them has been developed successfully as anti-AD drugs mainly because of deleterious side effects; the broad specificity of the MMP inhibitors must be a stiff obstacle for developing safe and effective drugs.

About 5 10% are the so-called familial cases, which can be mainly attributed to deleterious mutations in BRCA1 and BRCA2 (Dunning et al, 2001; Nathanson and Weber, 2001), and also for the remaining majority of spontaneous breast cancer cases a strong genetic component has been postulated (Lichtenstein et al, 2000).