Current models for the group I and group II intron active sites show an intricate set of Mg2+ ions that are mainly coordinated by phosphodiester groups and are reminiscent of the carboxylate-coordinated Mg2+ ions found in polymerase active sites.
On the other hand, contention-free protocols are mainly coordinated in nature involving a centralized master entity which allocates orthogonal or non-orthogonal resources to network users, using some policies defined by the scheduling algorithm.
The homo-clustered miRNAs mainly coordinate their regulation rapidly, while the hetero-clustered miRNAs exert control with a delay.
The observed bond lengthening between Tyr440 and the heme-iron in chains A and D, where Met362 mainly coordinates, supports this hypothesis.
The projects are mainly coordinated by universities or other public Institutions while companies and not-for-profit research organisations are involved as coordinators in two and four projects, respectively.
The case managers needed to explain that they were not taking the place of other professions; they mainly coordinated health and social care contacts.
The drug-induced protease mutations perturb the mechanistically crucial hinge axes that involve key sites for substrate binding and dimerization and mainly coordinate the intrinsic dynamics.
The physiological stress response is mainly coordinated by the hypothalamus, with activation of the ANS and the pituitary and adrenal glands (HPA axis) resulting in the release of catecholamines and cortisol, respectively [ 1, 9, 17].
The most variation being in the orientation of the fluctuations around the hinge axes implies that the protease mutations perturb the mechanistically crucial sites that mainly coordinate the intrinsic dynamics of the protease in interaction with its substrate.
Therefore, the interdependent nature of the substrate recognition allowing the protease to recognize various nonhomologous sequences as natural substrates may be partly due to this adaptability in the hinge regions which are the mechanistically crucial sites that mainly coordinate the intrinsic dynamics.
